Disease: HER2 gene amplification
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962
RARB P10826 retinoic acid receptor beta Nuclear receptor 1.00 0.478 0.846
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PGR P06401 progesterone receptor Nuclear receptor 5.1E-02 0.426 0.885
NCOA3 Q9Y6Q9 nuclear receptor coactivator 3 Kinase 0.54 0.522 0.654
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846
KRT20 P35900 keratin 20 9.1E-11 0.388 0.846
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923
KDR P35968 kinase insert domain receptor Kinase 1.00 0.378 0.885
GRB7 Q14451 growth factor receptor bound protein 7 Receptor 1.4E-06 0.603 0.462
GAST P01350 gastrin 2.7E-03 0.485 0.808
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923